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KMID : 0350519940470020985
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Journal of Catholic Medical College
1994 Volume.47 No. 2 p.985 ~ p.996
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The Effects of Low-Power Infrared Laser Irradiation on the Regeneration of Compressed Sciatic Nerves in Rats
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Abstract
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The purpose of this study is to examine the effect of low-power infrared laser irradiation on healing experimentally compressed sciatic nerves of rats. The bilateral sciatic nerves of 30 adult female Wistar rats were compressed surgically with a
straight hemostat.
The right legs of all the rats were irradiated using a 7 mW, 780 nm infrared laser (laser-irradiated group). The radiation procedure was administered for 5 minutes every day for 32 days. Left legs were not irradiated (control group).
A nerve conduction study was performed prior to compression and was repeated every fourth treatment day thereafter. The number of myelinated axons in the sciatic nerves of both legs was also measured in order to make a morphological analysis of
the
effect of the infrared laser on injured norves.
@ES The results are as follows:
@EN 1. The mean value of the latencies of the compound action potentials was significantly higher in the laser-irradiated group than in the control group 24 days after the nerve compression injury and increased to 1.2 times the pre-compression
value in
the laser-irradiated group and 1.4 times in the control group 32 days after injury.
2. The mean amplitude was significantly higher in the laser-irradiated group than in the control group 16 days after injury. The mean recovery rate of the amplitude to the pre-compression value was 27.5% in the laser-irradiated group and 19.8%
in
the
control group 16 days after injury and 49.7% in the laser-irradiated group and 29.0% in the control group 32 days after injury.
3. The mean number of myelinated axons began to increase 16 days after injury and was significantly higher in the laser-irradiated group than in the control group. The mean rate of the number of myelinated axons to normal axons was 56.2% in the
laser-irradiated group and 40.9% in the control group 16 days after injury and 74.8% in the laser-irradiated group and 50.5% in the control group 32 days after injury.
4. The number of myelinated axons was not significantly related to latency. It was, however, significantly related to amplitude in both groups. The correlation coefficient tended to be higher in the laser-irradiated group(r=0.593) than in the
control
group (r=0.378).
Taking the above results into consideration, it is suggested that low-power infrared laser irradiation is beneficial to the regeneration process of the peripheral nerve injury.
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